Komatsuzaki Group

Chun Biu LI

Associate Professor
  1. Molecule & Life Nonlinear Science Laboratory, Research Center of Mathematics for Social Creativity, Research Institute for Electronic Science
  2. Department of Mathematics, Applied Mathematics
Office:
Research Institute for Electronic Science, 5th floor, room 103-2
Mailing address:
Research Institute for Electronic Science, Hokkaido University, Kita 20 Nishi 10, Kita-ku, Sapporo 001-0020, Japan
FAX:
(+81)11-706-9437
E-mail:
cbli(at)es.hokudai.ac.jp

Full CV

 CV_ChunBiu_201604

Research Interests

My research is to develop new theoretical frameworks and methodologies to unveil the properties of complex phenomena in nature. In particular, the remarkable developments of biology offer us numerous special nonlinear complex systems in which the dynamics implement the “algorithm of life” and embody functions essential for survival in a complex, fluctuating environment. However, due to the highly complex nature of these systems and the difficulties in observing the solely dynamical behavior of an individual molecule free from averaging over an ensemble, the present understanding of fundamental nonlinear phenomena of biomolecules, such as functions, energy storage and transport properties of proteins in cell membranes and organelles, has been no further along than an anatomy or a presupposed thermodynamic energy landscapes on the microscopic levels. By the new methodologies and employing the recent establishments in nonlinear dynamics, information theory and nonequilibrium statistical mechanics, I would like to establish an integrated and quantitative understanding of biological systems, and shed new light on the origin and meaning of life.

My current research topics include:

Nonlinear Time Series Analysis:

  1. Understand the dynamics, function and structure of protein folding from the time series of single molecule experiments and MD simulation.
  2. Develop new tools to analyze nonlinear nonstationary time series based on information theory, network theory, nonlinear dynamics, and nonequilibrium statistical mechanics.
  3. Extract the hierarchical properties of spatial-temporal structures in biological system, e.g. information flow, casual relations, dynamics at each coarse grained level, coherent structures, etc.

Theory of Reaction Dynamics:

  1. Examine the fundamental assumption of reaction theories: Existence of no-return transition states and validity of ergodicity.
  2. Reveal the hierarchical nature of transition dynamics: Bifurcation and chaotic phenomena in transition dynamics
  3. Extract geometrical structures that mediate reactions, i.e., skeleton/roadmap of reaction dynamics, in multi-dimensional phase space.

Nonequilibrium Statistical Mechanics and nonlinear dynamics:

  1. Develop new theoretical framework to understand complex phenomena, e.g. emergence, self-organized structures and pattern formation, based on distribution and probabilistic approaches which goes beyond reductionism.
  2. Reformulate statistical mechanics to bridge the reversible microscopic dynamics and the irreversible macroscopic world.

Relevant publications

Book

2011

[2]Chun Biu Li, Tamiki Komatsuzaki
Extracting the Underlying Unique Reaction Scheme from a Single-Molecule Time Series in Cell Signaling Reactions: Single-Molecular Kinetic Analysis (Springer) , ISBN: 978-90-481-9863-4
(invited)

2017

[1]Meysam Tavakoli, J. Nicholas Taylor, Chun-Biu Li, Tamiki Komatsuzaki, Steve Pressé
Advances in Chemical Physics: "Single Molecule Data Analysis: An Introduction" Edited by Stuart A. Rice, Aaron R. Dinner (Wiley)

Papers

1995

[42]C.F. Lo, T.Y. Liu, C.B. Li
Squeezing properties of a pulsating oscillator
Quantum Semiclassical Optics 7, pp.843, (1995)

1997

[41]C.B. Li, D.C. Mattis
t-J Model with infinite-ranged hopping
Modern Physics Letters B 11(4), pp.115, (1997)

2003

[40]H.H. Hasegawa, D.J. Driebe, C.B. Li
Spectral decomposition of stretching dynamics of Arnold cat map
Physics Letters A 319(3-4), pp.290, (2003)

[39]H.H. Hasegawa, C.B. Li, Y. Ohtaki
Fractional power scaling of excess heat production
Physics Letters A 307, pp.222, (2003)

2004

[38]C.B. Li, D.J. Driebe, T. Petrosky
Resonance Overlap, Secular Effects and Non-integrability: An Approach from Ensemble Theory
Physical Review E 69, pp.066120, (2004)

[37]H.H. Hasegawa, C.B. Li, Y. Ohtaki
Thermodynamics of a system with long-time correlations
International Journal of Quantum Chemistry 98, pp.138, (2004)

2005

[36]Chun Biu Li, Yasuhiro Matsunaga, Mikito Toda, Tamiki Komatsuzaki
Phase Space Reaction Network on a Multisaddle Energy Landscape: HCN isomerization
Journal of Chemical Physics 123, pp.184301(1)-184301(13) (2005)

[35]Chun Biu Li, M. Toda, T. Komatsuzaki
Chaotic Reaction Dynamics and the Phase Space Geometry of Multidimensional Chemical Reaction
Bussei Kenkyu (Kyoto) 84(3), pp.481-482 (2005)

2006

[34]Gareth J. Rylance, Roy L. Johnston, Yasuhiro Matsunaga, Chun Biu Li, Akinori Baba, Tamiki Komatsuzaki
Topographical complexity of multidimensional energy landscapes
Proceedings of National Academy of Sciences USA 103, pp.18551, (2006)
This paper was selected in "Virtual Journal of Biological Physics Research "Protein Conformational Dynamics/Folding " 12(12) (2006)".

[33]Chun Biu Li, Akira Shojiguchi, Mikito Toda, Tamiki Komatsuzaki
Erratum: Dynamical Hierarchy in Transition States of Reactions
Few-Body Systems 40, pp.129-129 (2006)

[32]Chun Biu Li, Akira Shojiguchi, Mikito Toda, Tamiki Komatsuzaki
Erratum: Definability of No-Return Transition States in the High-Energy Regime above the Reaction Threshold [Phys. Rev. Lett. 97, 028302 (2006)]
Physical Review Letters 97, pp.129901, (2006)

[31]Akira Shojiguchi, Akinori Baba, Chun Biu Li, Tamiki Komatsuzaki, Mikito Toda
Wavelet Analysis and Arnold Web Picture for Detecting Energy Transfer in Hamiltonian Dynamical System
Laser Physics 16(7), pp.1097-1106 (2006)

[30]Chun Biu Li, Akira Shojiguchi, Mikito Toda, Tamiki Komatsuzaki
Definability of No-return Transition States in High Energy Regime Above Threshold
Physical Review Letters 97, pp.028302-028305 (2006)

[29]Chun Biu Li, Akira Shojiguchi, Mikito Toda, Tamiki Komatsuzaki
Dynamical Hierarchy in Transition States of Reactions
Few-Body Systems 38, pp.173-179 (2006)

[28]Chun Biu Li, M. Toda, T. Komatsuzaki
Geometrical Structure buried in the Phase Space of Stochastic Structural Transition
Bussei Kenkyu (Kyoto) 86(1), pp.77-81 (2006)

2007

[27]Akira Shojiguchi, Chun Biu Li, Tamiki Komatsuzaki, Mikito Toda
Fractional Behavior in Multi-Dimensional Hamiltonian Systems Describing Reactions
Physical Review E 76, pp.056205(1)-056205(14) (2007)

[26]Yasuhiro Matsunaga, Chun Biu Li, Tamiki Komatsuzaki
Anomalous Diffusion in Folding Dynamics on Minimalist Protein Landscape
Physical Review Letters 99, pp.238103, (2007)
This paper was selected in "Virtual Journal of Biological Physics Research "Protein Conformational Dynamics/Folding " 14(12)(2007)".

[25]Akira Shojiguchi, Chun Biu Li, Tamiki Komatsuzaki, Mikito Toda
'Fractional behavior in nonergodic reaction processes of isomerization
Physical Review E (rapid communication) 75, pp.035204(R), (2007)

[24]Shinnosuke Kawai, Yo Fujimura, Okitsugu Kajimoto, Takefumi Yamashita, Chun-Biu Li, Tamiki Komatsuzaki, Mikito Toda
Dimension reduction for extracting geometrical structure of multidimensional phase space: Application to fast energy exchange in the reaction O(1D)+N2O →NO+NO
Physical Review A 75, pp.022714, (2007)

2008

[23]Akira Shojiguchi, Chun Biu Li, Tamiki Komatsuzaki, Mikito Toda
Erratum: Fractional Behavior in Multi-Dimensional Hamiltonian Systems Describing Reactions
Physical Review E 77, pp.019902, (2008)

[22]Chun Biu Li, Haw Yang, Tamiki Komatsuzaki
Multiscale Complex Network of Protein Conformational Fluctuation Buried in Single Molecule Time Series
Proceedings of National Academy of Sciences USA 105, pp.536-541 (2008)
This paper was selected in "Virtual Journal of Biological Physics Research "Single Molecule Dynamics", 15(3) (2008)"

[21]Akira Shojiguchi, Chun Biu Li, Tamiki Komatsuzaki, Mikito Toda
Dynamical Foundation and Limitations of Statistical Reaction Theory
Communications in Nonlinear Science and Numerical Simulation 13, pp.857-657 (2008)

2009

[20]Chun Biu Li, Mikito Toda, Tamiki Komatsuzaki
Bifurcation of no-return transition states in many-body chemical reactions
Journal of Chemical Physics 130, pp.124116, (2009)

[19]Chun Biu Li, Haw Yang, Tamiki Komatsuzaki
New Quantification of Local Transition Heterogeneity of Multiscale Complex Networks Constructed from Single-Molecule Time Series
Journal of Physical Chemistry B 113(44), pp.14732-14741 (2009)

2010

[18]Tamiki Komatsuzaki, Chun Biu Li, Shinnosuke Kawai
Robustness and Diversity of Transitions in a Sea of Chaos and Stochastic Fluctuation
AIP Conference Proceedings "International Conference of Numerical Analysis and Applied Mathematics 2010" 1281(1), pp.1582-1584 (2010)

[17]Yasuhiro Matsunaga, Chun Biu Li, Tamiki Komatsuzaki
Collectivity at Different Space and Time Scales in Multiscale Protein Dynamics
Physical Review E 82, pp.016213, (2010)
This paper was selected in "Virtual Journal of Biological Physics Research "Protein Conformational Dynamics/Folding " 20(3) (2010)".

2011

[16]Naoki Miyagawa, Hiroshi Teramoto, Chun-Biu Li, Tamiki Komatsuzaki
Decomposability of Multivariate Interactions
Complex Systems 20, pp.165-179 (2011)

[15]Naoki Miyagawa, Hiroshi Teramoto, Chun-Biu Li, Tamiki Komatsuzaki
Spatial Heterogeneity of Multivariate Dependence
AIP Conference Proceedings ''International Conference of Numerical Analysis and Applied Mathematics 2011'' 1389, pp.991-991 (2011)

[14]David M. Leitner, Yasuhiro Matsunaga, Akira Shojiguchi, Chun-Biu Li, Tamiki Komatsuzaki, Mikito Toda
Non-Brownian Phase Space Dynamics of Molecules, the Nature of their Vibrational States, and non-RRKM Kinetics
Advances in Chemical Physics 145, pp.83-122 (2011)

[13]Shinnosuke Kawai, Hiroshi Teramoto, Chun-Biu Li, Tamiki Komatsuzaki, Mikito Toda
Dynamical Reaction Theory based on Geometric Structures of Phase Space
Advances in Chemical Physics 145, pp.123-170 (2011)

2012

[12]Tatyana Terentyeva, Hans Engelkamp, Alan Rowan, Tamiki Komatsuzaki, Johan Hofkens, Chun Biu Li, Kerstin Blank
Dynamic Disorder in Single Enzyme Experiments: Facts and Artifacts
ACS Nano 6(1), pp.346-354 (2012)
DOI: 10.1021/nn203669r
(Chosen as a highlighted article In Nano, Volume 6, issue 1(2012))

2013

[11]Tahmina Sultana, Hiroaki Takagi, Miki Morimatsu, Hiroshi Teramoto, Chun-Biu Li, Yasushi Sako, Tamiki Komatsuzaki
Non-Markovian properties and multiscale Hidden Markovian Network Buried in Single Molecule Time Series
The Journal of Chemical Physics 139, pp.245101-245101-12 (2013)
DOI: 10.1063/1.4848719
This paper was chosen as one of the most-accessed articles in Biological Molecules and Networks from The Journal of Chemical Physics.

[10]Yasuhiro Matsunaga, Akinori Baba, Chun Biu Li, John Straub, Mikito Toda, Tamiki Komatsuzaki, R. Stephen Berry
Spatio-temporal hierarchy in the dynamics of a minimalist protein model
The Journal of Chemical Physics 139, pp.215101-215101-13 (2013)
DOI: 10.1063/1.4834415

[9]Yutaka Nagahata, Hiroshi Teramoto, Chun-Biu Li, Shinnosuke Kawai, Tamiki Komatsuzaki
Reactivity boundaries for chemical reactions associated with higher index and multiple saddles
Physical Review E 88(4), pp.42923-42923-11 (2013)
DOI: 10.1103/PhysRevE.88.042923
(Figure 6d from this paper was selected to be displayed on PRE journal web site as part of "Kaleidoscope")

[8]Chun-Biu Li, Tamiki Komatsuzaki
Aggregated Markov Model Using Time Series of Single Molecule Dwell Times with Minimum Excessive Information
Physical Review Letters 111, pp.58301-58301-5 (2013)
DOI: 10.1103/PhysRevLett.111.058301

[7]Yutaka Nagahata, Hiroshi Teramoto, Chun-Biu Li, Shinnosuke Kawai, Tamiki Komatsuzaki
Reactivity Boundaries to Separate the Fate of a Chemical Reaction Associated with an Index-two saddle
Physical Review E 87(6), pp.62817 , (2013)
DOI: 10.1103/PhysRevE.87.062817

[6]Tatyana Terentyeva, Johan Hofkens, Tamiki Komatsuzaki, Kerstin Blank, Chun-Biu Li
Time-Resolved Single Molecule Fluorescence Spectroscopy of an α-Chymotrypsin Catalyzed Reaction
Journal of Physical Chemistry B 117 (5), pp.1252-1260 (2013)
DOI: 10.1021/jp310663v

2014

[5]Chun-Biu Li, Tamiki Komatsuzaki
Handling Noisy Data from Single Molecule Experiments
SEIBUTSU BUTSURI 54(5), pp.257-258 (2014)
DOI: 10.2142/biophys.54.257

[4]Preetom Nag, Hiroshi Teramoto, Chun-Biu Li, Joseph Z. Terdik, Norbert F. Scherer, Tamiki Komatsuzaki
Local-heterogeneous responses and transient dynamics of cage breaking
The Journal of Chemical Physics 141, pp.104907-1-104907-12 (2014)
DOI: 10.1063/1.4894866

2015

[3]C.B. Li, H. Ueno, R. Watanabe, H. Noji, T. Komatsuzaki
ATP hydrolysis assists phosphate release and promotes reaction ordering in F1-ATPase
Nature Communications 6(10223), (2015)
DOI: 10.1038/ncomms10223

[2]Chun Biu Li
Challenges in Constructing State-Space Network Models for Complex Systems at the Single Molecule Level
ASTE; Advances in Science, Technology and Environmentology, Special issue on New Challenges in Complex Systems Science B11, pp.51-54 (2015)

2016

[1]Satoru Tsugawa, Nathan Hervieux, Olivier Hamant, Arezki Boudaoud, Richard S. Smith, Chun-Biu Li, Tamiki Komatsuzaki
Extracting subcellular fibrillar alignment with error estimation: Application to microtubules
Biophysical Journal 110(8), pp.1836-1844 (2016)
DOI: 10.1016/j.bpj.2016.03.011

Presentation

2004

[83]Chun Biu Li
Multi-dimensional reaction dynamics in chaotic chemical process
Workshop on "Chaos and Nonlinear Dynamics in Quantum-Mechanical and Macroscopic Systems" (12.8-12.10 ,2004), Kyoto (poster)

2005

[82]Chun Biu Li, Yasuhiro Matsunaga, Mikito Toda, Tamiki Komatsuzaki
Geometrical Structure of Phase Space for Chemical Reaction Dynamics: What Kinds of Molecular Motions are Associated with Phase Space Modes in Chaos?
International Symposium on Atoms, Molecules, and Clusters in Intense Laser Fields 2 (1.24-1.25 ,2005), Tokyo (poster)

[81]Yasuhiro Matsunaga, Chun Biu Li, Tamiki Komatsuzaki
Time series analysis of collective motions in proteins
Telluride Summer Workshop "Energy Landscapes: Dynamics and Optimization"(7.24-8.6 ,2005), Telluride, Colorado USA (contributed talk)
organized by David J. Wales(Univ. of Cambridge),Christian Shoen (MPI) and Karl H. Hoffmann (TU Chemnitz),

[80]Chun Biu Li, Mikito Toda, Tamiki Komatsuzaki
Origin of Stochastic Transition on Multi-dimensional Energy Landscape
Telluride Summer Workshop "Energy Landscapes: Dynamics and Optimization"(7.24-8.6 ,2005), Telluride, Colorado USA (contributed talk)
organized by David J. Wales(Univ. of Cambridge),Christian Shoen (MPI) and Karl H. Hoffmann (TU Chemnitz),

[79]Chun Biu Li, Mikito Toda, Tamiki Komatsuzaki
Vibrational energy redistribution via geometrical structures in the multi-dimensional phase space of chemical reaction
Telluride Summer Workshop "Condensed Phase and Gas Phase Vibrational Dynamics"URL( ,2005), Telluride, Colorado USA 8, 6-13 (contributed talk)
organized by David M. Leitner (Univ. of Nevada) and Peter Hamm (University of Zurich),

[78]Chun Biu Li, Tamiki Komatsuzaki
Dynamical Hierarchy in Transitions of Chemical Reactions
International Symposium on Ultrafast Intense Laser Science 4HP(12.10-12.14 ,2005), Big Island, Hawaii

[77]Chun Biu Li, Yasuhiro Matsunaga, Mikito Toda, Tamiki Komatsuzaki
Geometrical structure of the multidimensional phase space transport in chemical reactions
Pacifichem 2005HP(12.15-12.20 ,2005), Honolulu, Hawaii

2006

[76]Chun Biu Li, Tamiki Komatsuzaki
Extracting Dynamics from Time Series Data of Single Molecule Experiments on a Photon-by-Photon Basis
Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan(11.12-11.16 ,2006), Okinawa

[75]Chun Biu Li, Tamiki Komatsuzaki
Extracting Protein Conformational Dynamics on a Photon-by-Photon Basis in Single Molecule Electron Transfer
Discussion on "Theory and simulation of biomolecular nano-machines"URL(12.12-12.16 ,2006), Maiko Villa, Kobe (poster)

2007

[74]Chun Biu Li
Detection of Phase Space Geometrical Structure Buried in Time Series
DYNAMICS OF COMPLEX SYSTEMS  - mathematical modeling, method and prediction -(on the celebration of 60th birthday of Profs. Y. Pesin and Y. Takahashi)(3.19-3.20 ,2007), Hokkaido University, Hokkaido, Japan (contributed talk)

[73]Akira Shojiguchi, Chun-Biu Li, Tamiki Komatsuzaki, Mikito Toda
Fractional behavior in Hamiltonian Chaos Describing Reactions
THE THIRD SHANGHAI INTERNATIONAL SYMPOSIUM ON NONLINEAR SCIENCES AND APPLICATIONS(6.6-6.11 ,2007), Shanghai, China (contributed talk)

[72]Chun Biu Li, Akira Shojiguchi, Mikito Toda, Tamiki Komatsuzaki
The Dynamical Origin of Chemical Reactions: How and Why Systems can React from One State to the Other
THE THIRD SHANGHAI INTERNATIONAL SYMPOSIUM ON NONLINEAR SCIENCES AND APPLICATIONS(6.6-6.11 ,2007), Shanghai, China (contributed talk)

[71]Chun-Biu Li, Tamiki Komatsuzaki
Extracting Protein Conformational Dynamics on a Photon-by-Photon Basis in Single Molecule Experiments
THE THIRD SHANGHAI INTERNATIONAL SYMPOSIUM ON NONLINEAR SCIENCES AND APPLICATIONS(6.6-6.11 ,2007), Shanghai, China (contributed talk)

[70]Yasuhiro Matsunaga, Chun-Biu Li, Tamiki Komatsuzaki
Anomalous Diffusion in Folding Dynamics of Minimalist Protein Landscape
THE THIRD SHANGHAI INTERNATIONAL SYMPOSIUM ON NONLINEAR SCIENCES AND APPLICATIONS(6.6-6.11 ,2007), Shanghai, China (contributed talk)

[69]Li Chun Biu, Tamiki Komatsuzaki
Capturing the multiple-time-scale dynamical state-network in the time series of single molecule experiments
ACS National Meeting: Single Molecule Spectroscopy, Imaging and Manipulation of Biomolecular Systems(8.19-8.23 ,2007), Boston (poster)

2008

[68]Li Chun Biu, Tamiki Komatsuzaki
Capturing the Multiple-Time-Scale Dynamical State-Space-Network in the Time Series of Single Molecule Experiment
1st Annual Protein and Peptide Conference(4.22-4.24 ,2008), Shenzhen (poster)

[67]Chun Biu Li
On the search of new mathematical frameworks to unveil the multiscale dynamics of complex systems
Workshop on Interfacial dynamics on the boundaries of physics, chemistry, biology and mathematics(11.20 ,2008), Hokkaido (invited)

[66]Chun Biu Li
Data-driven Modeling of Single Mechanosensitive Ion Channels from Time Series Analysis
Institute for Protein Research Seminar on New Approaches to Complexity of Protein Dynamics by Single Molecule Measurements: Experiments and Theories(12.7-12.9 ,2008), Osaka (invited talk)

[65]Kazuto Sei, Li Chun Biu, Tamiki Komatsuzaki
Toward the understanding of the gating dynamics for the mechanosensitive ion channel
Institute for Protein Research Seminar on New Approaches to Complexity of Protein Dynamics by Single Molecule Measurements: Experiments and Theories(12.7-12.9 ,2008), Osaka (poster)

2009

[64]K. Sei, C. Li, T. Nomura, H. Tatsumi, T. Komatsuzaki
Data-driven time series analysis of Mechanosensitive ion channel gating dynamics
6th Asian Biophysics Association (ABA) Symposium & 27th Hong Kong Society of Neuroscience Annual Meeting(1 ,2009), Hong Kong, China (poster)

[63]C. Li
Complex multi-scale networks of protein fluctuation dynamics from single-molecule time series
6th Asian Biophysics Association (ABA) Symposium & 27th Hong Kong Society of Neuroscience Annual Meeting(1 ,2009), Hong Kong, China

[62]Chun Biu Li
Multiscale Networks of Interacting Biological Systems: From network constructions to causality among them
Sapporo Winter School(2.10-2.14 ,2009), Hokkaido University (poster)

[61]Kazuto Sei, Chun Biu Li, Tamiki Komatsuzaki
Time series analysis of mechanosensetive ion channel dynamics
International Symposium on Reaction Dynamics of Many-Body Chemical systems(6.22-6.24 ,2009), Kyoto Univ. (poster)

[60]Chun Biu Li, Mikito Toda, Tamiki Komatsuzaki
Does No-return Transition State always exist above the Reaction Threshold?
International Symposium on Reaction Dynamics of Many-Body Chemical systems(6.22-6.24 ,2009), Kyoto Univ. (poster)

[59]Chun Biu Li
Data-driven Multiscale Modeling of Single Molecule Experiments from Time Series Analysis
International Symposium 'Innovative Nanoscience of Supermolecular Motor Proteins'(9.8-9.10 ,2009), Kyoto (poster)

2010

[58]Tamiki Komatsuzaki, Chun-Biu Li, Akinori Baba
Extracting Complex Network and Effective Free Energy Landscape of Protein Fluctuation From Single Molecule Time Series
Biophysical Society 54th Annual Meeting(2.10-2.24 ,2010), San Francisco,Calofornia, 20-24 (poster)

[57]Chun Biu Li, Haw Yang, Tamiki Komatsuzaki
Extracting and Quantifying the Multiscale Complex Networks Constructed from Single-Molecule Time Series
International Symposium on Joint Research Network on Advanced Materials and Devices 'Chou'(3 ,2010), Tomakomai, Hokkaido (poster)

[56]Tamiki Komatsuzaki, Chun Biu Li, Shinnosuke Kawai
Robustness and diversity of transitions in a sea of chaos and stochastic fluctuation
International Conference of Numerical Analysis and Applied Mathematics(9.19-9.25 ,2010), Greece (invited)

2011

[55]CB Li
Either contruction of KS from dwell-time time series, or modeling of QD blinking
Telluride Workshop on Complexity of Kinetics and Dynamics in Many Dimension(6.20-6.24 ,2011) (invited)

[54]CB Li
Multiscale Time Series Analysis of Supermolecular Motor Proteins on the Single Molecule Level
Telluride Workshop on Single Molecule Dynamics(6.27-7.1 ,2011) (invited)

[53]Naoki Miyagawa, Hiroshi Teramoto, Chun Biu Li, Tamiki Komatsuzaki
Spatial Heterogeneity of Multivariate Dependence
International Conference of Numerical Analysis and Applied Mathematics(9.19-9.25 ,2011), Greece (invited)

[52]Tahmina Sultana, Hiroshi Teramoto, Chun Biu Li, Tamiki Komatsuzaki
Extracting the reaction network buried in Single Molecule Time Series of Epidermal Growth Factor Receptor and Growth Factor Receptor-Bound Protein 2
12th RIES-Hokudai International Symposium (11.21-11.22 ,2011), Chateraise Gateaux Kingdom Sapporo (poster)

[51], Chun Biu Li, Tamiki Komatsuzaki
"EXTRACTING THE MOST UNBLIASED KINETIC SCHEME FROM SINGLE MOLECULE TIME" "Bio-inspired approaches:Micro- & Nano- Architectures, Materials & Imaging"
FRANCE-JAPAN WORKSHOP(10.11-10.12 ,2011), Institut Europeen de Chimie et Biologie - Bordeaux (poster)

[50]Chun-Biu Li, Tamiki Komatsuzaki
Data-driven modeling of the complex dynamics and kinetics of single motor protein
17th International Biophysics Congress(10.30-11.3 ,2011) (poster)

[49]Yutaka Nagahata, Shinnosuke Kawai, Hiroshi Teramoto, Chun-Biu Li, Tamiki Komatsuzaki
Deterministic properties of a saddle with two reactive degrees-of-freedoms
12th RIES-Hokudai International Symposium (11.21-11.22 ,2011), Chateraise Gateaux Kingdom Sapporo (poster)

[48]Naoki Miyagawa, Hiroshi Teramoto, Chun Biu Li, Tamiki Komatsuzaki
Extracting many-body interaction laws from an observation
12th RIES-Hokudai International Symposium (11.21-11.22 ,2011), Chateraise Gateaux Kingdom Sapporo (poster)

2012

[47]Tahmina Sultana, Hiroshi Teramoto, Chun Biu Li, Tamiki Komatsuzaki
Extracting the Reaction Network Buried in Single Molecule Time Series of Epidermal Growth Factor Receptor (EGFR) and Growth Factor Receptor-Bound Protein 2 (Grb2) in Cytoplasm
IGP International Symposium 2012(3.2 ,2012), Hokkaido University (oral)

[46]Chun-Biu Li
An information theoretic approach to dynamical irreversibility from time series
Dynamics of complex systems(3.7 ,2012), Hokkaido University (invited)

[45]Chun-Biu Li
Data-Driven Modeling of the Complex Kinetics and Dynamics from Single Protein Motor Rotation Experiments
Quantitative Developmental Biology(3.26 ,2012), RIKEN Center for Developmental Biology (CDB) (poster)

[44]Preetom Nag, Hiroshi Teramoto, Chun Biu Li, Tamiki Komatsuzaki
Extracting quasi-normally repelling material surface by re-formulating variational Lagrangian coherent structure(LCS) theory
The 13th RIES-Hokudai International Symposium (12.13-12.14 ,2012), Chateraise Gateaux Kingdom, Sapporo, Japan (poster)

2013

[43]Chun Biu Li
Time Series, Networks and Dynamics: A Perspective from the Information Theory
The 14th RIES-HOKUDAI International Symposium 網[mou](12. 11-12. 12 ,2013), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Japan 12, 11 (invited, oral)

[42]J. N. Taylor, Chun Biu Li, Shinnosuke Kawai, Tamiki Komatsuzaki
An Information-Theoretical Approach to Local Equilibrium State Analysis for Single-Molecule Time-Series
The 14th RIES-HOKUDAI International Symposium 網[mou](12. 11-12. 12 ,2013), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Japan 12, 11 (poster)

[41]Tahmina Sultana, Hiroaki Takagi, Miki Morimatsu, Hiroshi Teramoto, Chun Biu Li, Yasushi Sako, Tamiki Komatsuzaki
Scrutiny of Heterogeneity in Memory by Extracting Reaction Network Buried in Single Molecule Time Series of EGFR and Grb2
The 14th RIES-HOKUDAI International Symposium 網[mou](12. 11-12. 12 ,2013), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Japan 12, 11 (poster)

[40]Yutaka Nagahata, Hiroshi Teramoto, Takashi Horiyama, Chun Biu Li, Tamiki Komatsuzaki
Toward understanding hierarchical structure of complex reaction networks extracted from single molecule time series
The 14th RIES-HOKUDAI International Symposium 網[mou](12. 11-12. 12 ,2013), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Japan 12, 11 (poster)

[39]Preetom Nag, Hiroshi Teramoto, Chun Biu Li, Tamiki Komatsuzaki
Coherent dynamics in colloidal fluids in terms of Lagrangian Coherent Structures (LCSs)
The 14th RIES-HOKUDAI International Symposium 網[mou](12. 11-12. 12 ,2013), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Japan 12, 11 (poster)

[38]Naoki Miyagawa, Hiroshi Teramoto, Chun Biu Li, Tamiki Komatsuzaki
Information of multi-order correlation in pattern formation
The 14th RIES-HOKUDAI International Symposium 網[mou](12. 11-12. 12 ,2013), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Japan 12, 11 (poster)

[37]Kunihiko Ibe, Hiroshi Teramoto, Chun Biu Li, Tamiki Komatsuzaki
Extracting the Protein-folding Dynamics from Single Molecule Time Series
The 14th RIES-HOKUDAI International Symposium 網[mou](12. 11-12. 12 ,2013), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Japan 12, 11 (poster)

[36]Chun-Biu Li, Tamiki Komatsuzaki
Toward the Decoding of Single Nucleotides Tunneling Current by Change Point Analysis
G3meeting,Academia Sinica(10.21-10.22 ,2013) (Poster)

[35]James N. Taylor, Shinnosuke Kawai, Chun Biu Li, Tamiki Komatsuzaki
Let Systems Tell for themselves: Energy Landscape and Complex Network
G3meeting,Academia Sinica(10.21-10.23 ,2013), Taipei, Taiwan

[34]Chun-Biu Li
When Computational Mechanics Meets Single Molecule Time Series
2013 International Symposium on Nonlinear Theory and its Applications(9.8-9.11 ,2013), Santa Fe Community Convention Center, Santa Fe , US (invited, Oral)

[33]Yutaka Nagahata, Hiroshi Teramoto, Chun-Biu Li, Tamiki Komatsuzaki
Identifying states in Markov chain steady state network extracted from time series by finding minimum transition probability
The Complexity of Dynamics and Kinetics in Many Dimensions(6.18 ,2013), Telluride Intermediate School, Telluride, CO., US (Oral)

[32]Chun-Biu Li
Does Dynamic Disorder Exist in the Enzymatic Reactions on the Single Molecule Level?
The Complexity of Dynamics and Kinetics in Many Dimensions(6.16-6.17 ,2013), Telluride Intermediate School, Telluride, CO., US (Oral)

[31]Yutaka Nagahata, Hiroshi Teramoto, Chun-Biu Li, Shinnosuke Kawai, Tamiki Komatsuzaki
Reactivity Boundaries to Separate the Fate of a Chemical Reaction Associated with Multiple Saddles
Geometry of Chemical Reaction Dynamics in Gas and Condensed Phases ,Telluride Intermediate School(6.13 ,2013), Telluride, CO., US (Oral)

[30]Chun Biu Li, Tamiki Komatsuzaki
Toward deciphering molecular individuality in systems biology
Gordon Conference on Stochastic Physics in Biology: Foundations and Current Trends(1.13-1.18 ,2013), Ventura, CA, US (Poster)

2014

[29]Satoru Tsugawa, Chun-Biu Li, Tamiki Komatsuzaki
An extraction method of local microtubule alignments in Arabidopsis sepal
The 15th Ries-Hokudai International Symposium 響[hibiki](12.16-12.17 ,2014), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Hokkaido 12, 16 (poster)

[28]J.N. Taylor, Chun Biu Li, David R. Cooper, Christy F. Landes, Tamiki Komatsuzaki
Error-based Extraction of Effective Free Energy Landscapes from Experimental Single-Molecule Time-Series
The 15th Ries-Hokudai International Symposium 響[hibiki](12.16-12.17 ,2014), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Hokkaido 12, 16 (poster)

[27]Yuji Tamiya, Chun-Biu Li, Rikiya Watanabe, Hiroyuki Noji, Tamiki Komatsuzaki
Temperature Dependency of Molecular Motor
The 15th Ries-Hokudai International Symposium 響[hibiki](12.16-12.17 ,2014), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Hokkaido 12, 16 (poster)

[26]Yutaka Nagahata, Satoshi Maeda, Hiroshi Teramoto, Chun-Biu Li, Takashi Horiyama, Tetsuya Taketsugu, Tamiki Komatsuzaki
An extraction of embedded timescale hierarchies buried in complex reaction network
The 15th Ries-Hokudai International Symposium 響[hibiki](12.16-12.17 ,2014), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Hokkaido 12, 16 (poster)

[25]Preetom Nag, Hiroshi Teramoto, Chun Biu Li, Joseph Z. Terdik, Norbert F. Scherer, Tamiki Komatsuzaki
Local-heterogeneous responses and transient dynamics in colloidal fluids
The 15th Ries-Hokudai International Symposium 響[hibiki](12.16-12.17 ,2014), CHÂTERAISÉ Gateaux Kingdom SAPPORO, Sapporo, Hokkaido 12, 16 (poster)

[24]Yuji Tamiya, Chun-Biu Li, Rikiya Watanabe, Hiroyuki Noji, Tamiki Komatsuzaki
Data Driven Approach to Dynamics of Protein Motor
New Challenges in Complex Systems Science(10.24-10.26 ,2014), Nishiwaseda Campus, Waseda University, Tokyo, Japan 10, 25 (poster)

[23]Chun Biu Li
Challenges in Understanding Complex Systems at the Single Molecule Level
New Challenges in Complex Systems Science(10.24-10.26 ,2014), Nishiwaseda Campus, Waseda University, Tokyo, Japan 10, 25 (invited, oral)

2015

[22]Nick Taylor, Almar F. Palonpon, Chun Biu Li, Katsumasa Fujita, Tamiki Komatsuzaki
Data-driven quantification of heterogeneous microenvironments in live-cell Raman microscopic images
Symposium #121 Deciphering molecular complexity from protein functions to cellular network (The 2015 International Chemical Congress of Pacific Basin Societies)(12.15-12.16 ,2015), Convention Center, Hawaii, USA 12, 16 (oral)

[21]Yutaka Nagahata, Satoshi Maeda, Hiroshi Teramoto, Chun-Biu Li, Tetsuya Taketsugu, Tamiki Komatsuzaki
Developing high precision algorithm to predict observation timescale hierarchy of an isomerization reaction network
The 16th RIES-Hokudai International Symposium(11.10-11.11 ,2015), Chateraise Gateaux Kingdom Sapporo, Sapporo, Japan 11, 10 (Poster)

[20]Genming Wang, Chun-Biu Li, Hitoshi Tatsumi, Tamiki Komatsuzaki
Kinetics of Multiple conductance levels of Mechanosensitive Ion Channel
The 16th RIES-Hokudai International Symposium(11.10-11.11 ,2015), Chateraise Gateaux Kingdom Sapporo, Sapporo, Japan 11, 10 (Poster)

[19]Yuji Tamiya, Chun-Biu Li, Rikiya Watanabe, Hiroyuki Noji, Tamiki Komatsuzaki
The Onset of Non-equilibrium Effects at High Temperature in the Reaction Kinetics of F1-ATPase
The 16th RIES-Hokudai International Symposium(11.10-11.11 ,2015), Chateraise Gateaux Kingdom Sapporo, Sapporo, Japan 11, 10 (Poster)

[18]Chun-Biu Li
The Key and Unlock Mechanisms in F1-ATPase Unveiled by Single Molecule Time Series Analysis
The 4th Workshop on Molecular & Chemical Kinetics(9.7-9.9 ,2015), Berlin, Germany (invited talk)

[17]Chun-Biu Li
Searching for New Mathematical Frameworks to Understand Complex Systems in the Real World
Cross-border Forum of “Money problems, Job market, and Chaos: mathematical and economical perspective on distribution of value from a viewpoint of Italy’s and Japan’s Economy(7.29 ,2015), Hokkaido Univ., Sapporo, Japan 7, 29 (invited talk)

[16]Nick Taylor, Chun Biu Li, David R. Cooper, Christy F. Landes, Tamiki Komatsuzaki
Error-based Extraction of States and Energy Landscapes from Experimental Single-Molecule Time-Series
The Complexity of Dynamics Kinetics from Single Molecules to Cells(6.14-6.18 ,2015), Telluride Elementary School, Telluride, CO, U.S. 6, 18 (Oral)

[15]Chun-Biu Li
The Roles of ATP Hydrolysis Revealed by Single Molecule Time Series Analysis of Rotary Fluctuations in F1-ATPase
The Complexity of Dynamics Kinetics from Single Molecules to Cells(6.14-6.18 ,2015), Telluride Elementary School, Telluride, CO, U.S. 6, 14 (invited,oral)

[14]Yutaka Nagahata, Satoshi Maeda, Hiroshi Teramoto, Chun-Biu Li, Takashi Horiyama, Tetsuya Taketsugu, Tamiki Komatsuzaki
Deciphering timescale hierarchy encoded in complex reaction networks
31st Symposium on Chemical Kinetics and Dynamics(6.3-6.5 ,2015), Frontier Research in Applied Sciences Bldg., Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido 6, 3 (poster)

[13]Chun-Biu Li
Robust Construction of Dwell-Time Statistics from Experimental and Simulation Time Series
Department seminar(4.17 ,2015), Max Planck Institute of Colloids and Interfaces, Potsdam, Germany 4, 17 (invited talk)

[12]Chun-Biu Li
Time Series, Networks and Dynamics: Constructing Hidden Markov Model from Information Theory
Department seminar(4.14 ,2015), Department of Mathematics, Computer Science and Bioinformatics, Free University of Berlin, Germany 4, 14 (invited talk)

[11]Yutaka Nagahata, Hiroshi Teramoto, Takashi Horiyama, Chun-Biu Li, Tamiki Komatsuzaki
Timescale hierarchies of complex reaction network
Workshop on dynamical systems and computation 2015‎(3.3-3.6 ,2015), Hokkaido University, Sapporo, Hokkaido 3, 4 (oral)

[10]Chun Biu Li
Single Molecule Time Series Analysis of F1-ATPase to Unravel the Role of ATP Hydrolysis and Thermal Fluctuations
Seminar at Max Planck Institute of Colloids and Interfaces(1.7 ,2015), Max Planck Institute of Colloids and Interfaces, Potsdam, Germany 1, 7 (invited, oral)

[9]Bo Shuang, David Cooper, J. Nick Taylor, Lydia Kisley, Jixin Chen, Wenxiao Wang, Chun Biu Li, Tamiki Komatsuzaki, Chrisy Landes
Fast Step Transition and State Identification (STaSI) for Discrete Single-Molecule Data Analysis
The 2015 Quantitative BioImaging Conference(1.7-1.9 ,2015), Institut Pasteur, Paris, France (poster)

2016

[8]Yuji Tamiya, Chun-Biu Li, Rikiya Watanabe, Hiroyuki Noji, Tamiki Komatsuzaki
The Non-equilibrium Effects on Reaction Kinetics of F1-ATPase
The 17th RIES-Hokudai International Symposium(12.13-12.14 ,2016), Chateraise Gateaux Kingdom Sapporo, Sapporo, Hokkaido 12, 13 (Poster)

[7]J.N. Taylor, Chun-Biu Li, Katsumasa Fujita, Tamiki Komatsuzaki
Data-Driven Approaches to Raman Microscopic Image Analysis
The 17th RIES-Hokudai International Symposium(12.13-12.14 ,2016), Chateraise Gateaux Kingdom Sapporo, Sapporo, Hokkaido 12, 13 (Poster)

[6]Preetom Nag, Khalifa Mohammad Helal, Hiroshi Teramoto, Chun-Biu Li, Hisashi Haga, Tamiki Komatsuzaki
Dynamical Heterogeneity During Collective Migration of MDCK Epithelial Monolayer
The 17th RIES-Hokudai International Symposium(12.13-12.14 ,2016), Chateraise Gateaux Kingdom Sapporo, Sapporo, Hokkaido 12, 13 (Poster)

[5]Khalifa Mohammad Helal, Preetom Nag, Hiroshi Teramoto, Chun Biu Li, Hisashi Haga, Tamiki Komatsuzak
Collective Cell Migration: Underlying Dynamics and Emergent Structures of Heterogeneity
The 17th RIES-Hokudai International Symposium(12.13-12.14 ,2016), Chateraise Gateaux Kingdom Sapporo, Sapporo, Hokkaido 12, 13 (Poster)

[4]Chun-Biu Li
A Nano-Scale Key-and-Unlock Mechanism in the F1-ATPase revealed by Single Molecule Time Series Analysis
Seminar at Beijing Computational Science Research Center(5.20 ,2016), Beijing Computational Science Research Center, Beijing, China 5, 20 (invited, oral)

[3]Chun Biu Li
From single molecule time series to networks and dynamics: approaches from information theory
Conference on the Time in Biological Systems and Beyond(3.28-3.29 ,2016), National Tsing Hua University, Hsinchu, Taiwan 3, 29 (invited, oral)

[2]J. Nick Taylor, Almar F. Palonpon, Chun Biu Li, Katsumasa Fujita, Tamiki Komatsuzaki
Data-driven quantification of heterogeneous microenvironments in live-cell Raman microscopic images
The Biophysical Society 2016 BPS Annual Meeting(2.27-3.2 ,2016), Los Angeles Convention Center, Los Angeles, USA 2, 27 (oral)

[1]Chun Biu Li
Time Series, Networks and Dynamics: Constructing Hidden Markov Model from Information Theory
Department Seminar in Department of Chemistry, Computational Biophysical Chemistry(2.22 ,2016), Hong Kong University, Hong Kong, China 2, 22 (invited, oral)

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