Komatsuzaki Group

Goro NISHIMURA

gnishimura Assistant Professer
Personal Homepage:HP

  1. Molecule & Life Nonlinear Sciences Laboratory, Research Center of Mathematics for Social Creativity, Research Institute for Electronic Science
  2. Graduate School of Life Science, Transdisciplinary Life Science Course
E-mail:
gnishi(at)imd.es.hokudai.ac.jp
TEL:
+81-11-706-3371
Office
Research Institute for Electronic Science, N12-building, 4-105-2
Mail:
Research Institute for Electronic Science, Hokkaido University, N20W10, Kita-ku, Sapporo 001-0020, Japan

Research Interests

My primary interest is in the study of optical methodology, biomedical optics, which is applicable to the biological and medical uses, and in the study of the physics on the biomedical optics. In particular, I am interested in the time-resolved spectroscopy and the correlation spectroscopy from the single-molecule level to the individual tissue level of small animals or human. I am currently focused on the tissue optics in a near-infrared region over 1 μm wavelength to obtain new information such as the water and structure of tissues. Since this region is essentially free or negligible from the heme absorption, this region could be used for a new optical window of the tissue, where the structure and dynamics are directly monitored. Further, the quantitative measurements of the extrinsic probe signals, such as fluorescence and scattering, are possible. I am expecting that this near-infrared wavelength region is key of yielding the detail information of complex hierarchical biological system.

Relevant publications

  1. Kamlesh Awasthi and Goro Nishimura, Modification of near-infrared cyanine dyes by serum albumin protein, Photochem. Photobiol. Sci. 10 (2011) 461-463.
  2. G.Nishimura, Kamlesh Awasthi, Kitsakorn Locharoenrat, Shinpei Okawa and Yukio Yamada, Time-domain fluorescence diffuse optical tomography for living animals by total-light algorithm, SPIE Proc. 7896 (2011) 78962Q1-77962Q7.
  3. Goro Nishimura, Changi Pack and Mamoru Tamura, Expansion of intensity correlation spectroscopy for lifetime measurements – application to intracellular oxygen dynamics measurements, Journal of Biomedical Optics 12 (2007) 020503.
  4. G.Nishimura, C.Pack and M.Tamura, Phosphorescence decay time measurements using intensity correlation spectroscopy, Exp.Mol.Pathol., 82 (2007) 175-183.
  5. G.Nishimura, I.Kida and M.Tamura, Characterization of optical parameters with a human forearm at the region from 1.15 to 1.52 μm using diffuse reflectance measurements, Phys.Med.Biol., 51 (2006) 2997-3011.
  6. G.Nishimura and M.Tamura, Artefacts in the analysis of temporal response functions measured by photon counting, Phys.Med.Biol., 50 (2005) 1327-1342.
  7. G.Nishimura and M.Tamura, Simple peak shift analysis of time-of-flight data with a slow instrumental response function, J.Biomed.Opt., 10 (2005) 014016.
  8. G.Nishimura and M.Kinjo, Systematic error in fluorescence correlation measurements identified by a simple saturation model of fluorescence, Anal.Chem., 76 (2004) 1963-1970.

Partial List of Professional Service

  • The Physical Society of Japan
  • The Biophysical Society of Japan
  • The Optical Society of Japan
  • Optical Society of America