Chun Biu LI

Associate Professor
1)Molecule & Life Nonlinear Science Laboratory, Section of Mathematical and System Sciences, Research Institute for Electronic Science
2) Department of Mathematics, Applied Mathematics
3) Research Center for Integrative Mathematics

WWW Page (personal):coming soon

• Office: Research Institute for Electronic Science, 5th floor, room 103-2
• Mailing address: Research Institute for Electronic Science, Hokkaido University, Kita 20 Nishi 10, Kita-ku, Sapporo 001-0020, Japan
• FAX:(+81)11-706-9437
• e-mail: cbli(at)es.hokudai.ac.jp

Research Interests:

My research is to develop new theoretical frameworks and methodologies to unveil the properties of complex phenomena in nature. In particular, the remarkable developments of biology offer us numerous special nonlinear complex systems in which the dynamics implement the "algorithm of life" and embody functions essential for survival in a complex, fluctuating environment. However, due to the highly complex nature of these systems and the difficulties in observing the solely dynamical behavior of an individual molecule free from averaging over an ensemble, the present understanding of fundamental nonlinear phenomena of biomolecules, such as functions, energy storage and transport properties of proteins in cell membranes and organelles, has been no further along than an anatomy or a presupposed thermodynamic energy landscapes on the microscopic levels. By the new methodologies and employing the recent establishments in nonlinear dynamics, information theory and nonequilibrium statistical mechanics, I would like to establish an integrated and quantitative understanding of biological systems, and shed new light on the origin and meaning of life.

My current research topics include:

• Nonlinear Time Series Analysis:
  1. Understand the dynamics, function and structure of protein folding from the time series of single molecule experiments and MD simulation.
  2. Develop new tools to analyze nonlinear nonstationary time series based on information theory, network theory, nonlinear dynamics, and nonequilibrium statistical mechanics.
  3. Extract the hierarchical properties of spatial-temporal structures in biological system, e.g. information flow, casual relations, dynamics at each coarse grained level, coherent structures, etc.
• Theory of Reaction Dynamics:
  1. Examine the fundamental assumption of reaction theories: Existence of no-return transition states and validity of ergodicity.
  2. Reveal the hierarchical nature of transition dynamics: Bifurcation and chaotic phenomena in transition dynamics
  3. Extract geometrical structures that mediate reactions, i.e., skeleton/roadmap of reaction dynamics, in multi-dimensional phase space.
• Nonequilibrium Statistical Mechanics and nonlinear dynamics:
  1. Develop new theoretical framework to understand complex phenomena, e.g. emergence, self-organized structures and pattern formation, based on distribution and probabilistic approaches which goes beyond reductionism.
  2. Reformulate statistical mechanics to bridge the reversible microscopic dynamics and the irreversible macroscopic world.

Relevant publications:

• Tatyana Terentyeva, Hans Engelkamp, Alan Rowan, Tamiki Komatsuzaki, Johan Hofkens, Chun Biu Li, Kerstin Blank, "Dynamic Disorder in Single Enzyme Experiments: Facts and Artifacts" ACS Nano 6 (1), 346-354(2012).
• Naoki Miyagawa, Hiroshi Teramoto, Chun-Biu Li and Tamiki Komatsuzaki, 'Decomposability of Multivariate Interactions' Complex Systems 20,165--179(2011) (invited).
• Naoki Miyagawa, Hiroshi Teramoto, Chun-Biu Li and Tamiki Komatsuzaki, 'Spatial Heterogeneity of Multivariate Dependence' AIP Conference Proceedings "International Conference of Numerical Analysis and Applied Mathematics 2011" 1389, 991 (2011) .
• C. B. Li and T. Komatsuzaki : "Extracting the Underlying Unique Reaction Scheme from a Single-Molecule Time Series", Cell Signaling Reactions: Single-Molecular Kinetic Analysis (Springer)(2011) (invited)
• David M. Leitner, Yasuhiro Matsunaga, Akira Shojiguchi, Chun-Biu Li, Tamiki Komatsuzaki, and Mikito Toda "Non-Brownian Phase Space Dynamics of Molecules, the Nature of their Vibrational States, and non-RRKM Kinetics" Advances in Chemical Physics145 ed. by T. Komatsuzaki, R. S. Berry, D.M. Leitner John-Wiley & Sons, Inc. ISBN: 978-0-470-643 (2011)
• Shinnosuke Kawai, Hiroshi Teramoto, Chun-Biu Li, Tamiki Komatsuzaki, Mikito Toda, "Dynamical Reaction Theory based on Geometric Structures of Phase Space" Advances in Chemical Physics 145 ed. by T. Komatsuzaki, R. S. Berry, D.M. Leitner John-Wiley & Sons, Inc. ISBN: 978-0-470-643 (2011)
• Tamiki Komatsuzaki, Chun Biu Li, and Shinnosuke Kawai 'Robustness and Diversity of Transitions in a Sea of Chaos and Stochastic Fluctuation' AIP Conference Proceedings "International Conference of Numerical Analysis and Applied Mathematics 2010" 1281(1), 1582-1584 (2010) (invited).
• Yasuhiro Matsunaga, Chun Biu Li, and Tamiki Komatsuzaki 'Collectivity at Different Space and Time Scales in Multiscale Protein Dynamics' Physical Review E 82, 016213[12 pages] (2010)
• Chun Biu Li, Haw Yang, and Tamiki Komatsuzaki: "New Quantification of Local Transition Heterogeneity of Multiscale Complex Networks Constructed from Single-Molecule Time Series", Journal of Physical Chemistry B, 113 (44), 14732-14741 (2009)
• Chun Biu Li, Mikito Toda, and Tamiki Komatsuzaki 'Bifurcation of no-return transition states in many-body chemical reactions' Journal of Chemical Physics 130, 124116 (2009)
• Chun Biu Li, Haw Yang, and Tamiki Komatsuzaki 'Multiscale Complex Network of Protein Conformational Fluctuation Buried in Single Molecule Time Series' Proceedings of National Academy of Sciences USA,105, 536-541 (2008).
• Akira Shojiguchi,Chun Biu Li, Tamiki Komatsuzaki, and Mikito Toda 'Dynamical Foundation and Limitations of Statistical Reaction Theory' Communications in Nonlinear Science and Numerical Simulation 13,857-657 (2008)
• Akira Shojiguchi,Chun Biu Li, Tamiki Komatsuzaki, and Mikito Toda 'Fractional Behavior in Multi-Dimensional Hamiltonian Systems Describing Reactions' Physical Review E 76, 056205(14pages) (2007).
• Yasuhiro Matsunaga, Chun Biu Li, and Tamiki Komatsuzaki 'Anomalous Diffusion in Folding Dynamics on Minimalist Protein Landscape' Physical Review Letters 99, 238103 (2007).
• Akira Shojiguchi,Chun Biu Li, Tamiki Komatsuzaki, and Mikito Toda 'Fractional behavior in nonergodic reaction processes of isomerization' Physical Review E (rapid communication) 75, 035204(R) (2007).
• S. Kawai,Y. Fujimura, O. Kajimoto, T. Yamashita, C.B. Li, T. Komatsuzaki, M. Toda ‘Dimension Reduction for Extracting Geometrical Structure of Multidimensional Phase Space: Application to Fast Energy Exchange in the Reaction O(1D)+N2O →NO+NO’ Physical Review A, Vol 75, pp022714 (2007).
• G.J. Rylance, R.L. Johnston, Y. Matsunaga, C.B. Li, A. Baba, T. Komatsuzaki, ‘Topographical Complexity of Multidimensional Energy Landscapes’, Proceedings of National Academy of Sciences USA, Vol 103, pp18551 (2006).
• A. Shojiguchi, A. Baba, C.B. Li, T. Komatsuzaki, M. Toda ‘Wavelet Analysis and Arnold Web Picture for Detecting Energy Transfer in Hamiltonian Dynamical System’ Laser Physics, Vol 16, pp1097 (2006).
• C.B. Li, A. Shojiguchi, M. Toda, T. Komatsuzaki ‘Definability of No-return Transition States in High Energy Regime above Threshold’ Physical Review Letters, Vol 97, pp028302 (2006).
• Chun Biu Li, Akira Shojiguchi, Mikito Toda, and Tamiki Komatsuzaki 'Dynamical Hierarchy in Transition States of Reactions', Few-Body Systems ,38,173-179 (2006).
• Chun Biu Li, Yasuhiro Matsunaga, Mikito Toda, and Tamiki Komatsuzaki 'Phase Space Reaction Network on a Multisaddle Energy Landscape: HCN isomerization' ,Journal of Chemical Physics 123,184301(1)-184301(13)(2005)
• C.B. Li, D.J. Driebe, T. Petrosky, "Resonance Overlap, Secular Effects and Non-integrability: An Approach from Ensemble Theory", Physical Review E, Vol. 69, pp066120 (2004).
• H.H. Hasegawa, C.B. Li, Y. Ohtaki, "Thermodynamics of a system with long-time correlations", International Journal of Quantum Chemistry, Vol. 98, pp138 (2004).
• H.H. Hasegawa, D.J. Driebe, C.B. Li, "Spectral decomposition of stretching dynamics of Arnold cat map", Physics Letters A, Vol. 319/3-4. pp290 (2003).
• H.H. Hasegawa, C.B. Li, Y. Ohtaki, "Fractional power scaling of excess heat production", Physics Letters A, Vol. 307, pp222 (2003).
• C.B. Li, D.C. Mattis, "t-J Model with infinite-ranged hopping", Modern Physics Letters B, Vol. 11, No. 4, pp115 (1997).
• J. Baker, C.B. Li, "The two-phase approximation for black hole collision: is it robust?", Classical and Quantum Gravity, Vol. 14, L77 (1997).
• C.F. Lo, T.Y. Liu, C.B. Li, "Squeezing properties of a pulsating oscillator", Quantum Semiclassical Optics, Vol. 7, pp843 (1995).

Partial List of Professional Service:

• Member, American Physical Society
• Member, Biophysical Society of Japan

updated date: 1/June/2012